The Deeper Genome: Why There Is More to the Human Genome Than Meets the Eye
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The Deeper Genome: Why There Is More to the Human Genome Than Meets the Eye

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The Deeper Genome: Why There Is More to the Human Genome Than Meets the EyeOver a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought just over 20,000, the same sort of number as a fruit fly or worm. What's more,

Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought -- just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?

Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.


Binding Type: Paperback
Publisher: Oxford University Press, USA
Published: 10/24/2017
ISBN: 9780198813095
Pages: 400
Weight: 0.60lbs
Size: 7.60h x 5.00w x 0.90d
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SKU: 74412557142

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me
Omaha, US
★★★★★ 3
Just aren’t large enough.
This is a great idea, and I can wear socks over them and not notice they are there. I just wish they came in a larger size. When I put cream around the edges of my heels where the cracks always are, I cannot stretch the socks wide enough to clear the heel without smearing the cream onto my fingers or on the sock cuff. They do stay in place and aren't squishy at all when walking. They smell good too. The price is right. I wore them overnight and my heels were indeed much softer and smoother than before, and felt moist (tacky) where the cream had been. So they do an amazing job, but after using them six nights, they just aren’t large enough for me to put on without a hassle.
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Reviewed in the United States on April 28, 2024
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MsNomer
Chelsea, US
★★★★★ 5
these really work
saved my poor cracking heels
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K. Davis
Dallas, US
★★★★★ 5
Works for foot psoraisis
Size: 2 pairs black L
Got these for work (service industry) to reduce issues with psoriasis and blisters while putting on 20k+ steps a day. Over time the wounds healed and I could work without so much pain. I now don't use them all the time like I used to, only when a new lesion or blister appears, too prevent a breakout. Tip: if you're not in full breakout, wear thick socks under these as a barrier to friction.
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Reviewed in the United States on April 28, 2026
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Kim C
Draper, US
★★★★★ 4
Work well but run small
Size: 1 pair black L
They do seem to run a bit small. I bought them for my bf but snagged them from him because I couldn’t resist! I’m about a W8/12 and they were just a little big but unlike others, I just put them on while sleeping and didn’t walk around with them. If you’re just planning on that, they did a great job at sloughing and moisturizing 😎
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Reviewed in the United States on April 25, 2026
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Aaron Duncan
West Palm Beach, US
★★★★★ 5
Good socks they work.
Size: 2 pairs black L
I normally wear size 13&half to 14 men's, and these fit me ok. They sit just below the ankle. They can get a little tight for me so you should look out for that if you are on the thicker side. But they work as advertised and help moisturize your feet. I recommend wearing them if you're going to just be hanging around home for a bit in one spot as they can be a little slippery to walk in if you go fast. Would not recommend going up and down stairs.
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Reviewed in the United States on August 28, 2025

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