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Description
CD10/Neprilysin/MME His Tag Protein, MouseProduct Specification Species Mouse Synonyms MME,CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP,SFE,Neprilysin Accession Q61391 Amino Acid Sequence Tyr52 Trp750, with N terminal His Expression System HEK293 Molecular Weight 85 95kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the
Product Specification
| Species | Mouse |
| Synonyms | MME,CALLA,CD10,DKFZp686O16152,MGC126681,MGC126707,NEP,SFE,Neprilysin |
| Accession | Q61391 |
| Amino Acid Sequence | Tyr52-Trp750, with N-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 85-95kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Review FASEB J . 1989 Feb;3(2):145-51. |
Background
Neprilysin (NEP, neutral endopeptidase 24.11, EC 3.4.24.11) is a zinc metallopeptidase, a 90-110-kDa type II transmembrane glycoprotein, which is usually expressed in a variety of tissues. Including the epithelial cells of the prostate, kidneys, intestines, endometrium, adrenal glands, and lungs. NEP has been identified as a common acute lymphoblastic leukemia antigen (CALLA) and is expressed on the surface of lymphocytes in certain disease states. Mutations in the CD10 gene can induce the familial forms of Alzheimer's disease, providing strong evidence for the protein's association with the Alzheimer's disease process.
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