CD40/TNFRSF5 His Tag Protein, Cynomolgus
SKU: 98976281071

CD40/TNFRSF5 His Tag Protein, Cynomolgus

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Description

CD40/TNFRSF5 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50 Accession G7PG38 Amino Acid Sequence Glu21 Arg193, with C terminal His Expression System HEK293 Molecular Weight 26 33kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after

Product Specification


Species Cynomolgus
Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Accession G7PG38
Amino Acid Sequence Glu21-Arg193, with C-terminal His
Expression System HEK293
Molecular Weight

26-33kDa

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Reference

1、van Kooten C. et al. (2000) CD40-CD40 ligand. J Leukoc Biol. 67(1): 2-17.

2、Bhushan A. et al. (2002) CD40: CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24(3): 311-324.

3、Chatzigeorgiou A. et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-483.

4、Li R. et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-3917.

Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.

Background

CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed its role in humoral immunity. Both CD40 and CD40 L have a membrane form and a soluble form generated by proteolytic cleavage or alternative splicing. CD40 and CD40L are widely expressed in various types of cells, among which B cells and myeloid cells constitutively express high levels of CD40, and T cells and platelets express high levels of CD40L upon activation. CD40L self-assembles into functional trimers which induces CD40 trimerization and downstream signaling. CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling. CD40/CD40L interaction also participates in regulating thrombosis, tissue inflammation, hematopoiesis and tumor cell fate. The mechanisms of benefits include immune cell activation and tumor cell lysis/apoptosis in malignancies, or immune cell inactivation in autoimmune diseases and allograft rejection.

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SKU: 98976281071

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Lisa B
Chelsea, US
★★★★★ 5
My dogs favorite!
My dogs love these! They will play all day if you'd let them, these balls are their favorites. I use the chuck-it handle and they get tons of exercise in the big yard!
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Reviewed in the United States on April 22, 2026
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Theredirishman
Alexandria, US
★★★★★ 5
The Dog LOVES IT!
I bought this for my ex-wife's Pitbull. He is an aggressive chewer and usually destroys any toy I buy him. But not this one! The ball is small enough and pliable that it gives when he chomps on it. He loves this ball and seems to be his favorite toy. Thank you for making a product that he likes and can't destroy!
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Reviewed in the United States on December 30, 2024
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Sean
Belleville, US
★★★★★ 5
My Golden Retriever’s favorite
We’ve owned lots of toys and balls. This specific version (in blue) has been her absolute favorite. She’s about 72lbs and chews on this thing regularly with no visible damage. We actually own about 6 of them because they have a tendency to go missing underneath furniture and in the yard. We have two of the orange colored ones but she doesn’t like those nearly as much which I assume is because the blue is easier to see in the grass. Other than that…They bounce really well and also whistle a little when you throw them hard enough. I hope they never stop making these.
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Reviewed in the United States on October 6, 2024
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Alp acct
Natrona Heights, US
★★★★★ 4
doesn't whistle as loud as other chuckit balls I've seen, but a good ball.
makes some noise, but I've seen (and played with) others at the dog park that whistle much louder than the 1 I got. all Chuckit balls... so, just this one I'm betting. but it flys good and the dog loves to chase it. he chews it a fair bit as well and the ball has not taken much damage from him (lab mix) or others that have had a go at it. I'll likely buy another at some point ... just wish it was a little louder when flying.
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Reviewed in the United States on November 4, 2025
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KA
Louisville, US
★★★★★ 5
Blue ball, my dog likes blue.
Just a ball right? Evidently not! My dog won’t chase an orange chuck it ball or the glow in the dark ball- only the blue one 🤷🏼‍♀️
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Reviewed in the United States on May 9, 2025

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