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Description
IKAROS Recombinant Rabbit mAb (S-R264)Product Specification Host Rabbit Antigen IKAROS Synonyms DNA binding protein Ikaros, Ikaros family zinc finger protein 1, Lymphoid transcription factor LyF 1, IKZF1, IK1, LYF1, ZNFN1A1 Location Nucleus Accession Q13422 Clone Number S R264 Antibody Type Recombinant mAb Application IHC P, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | IKAROS |
| Synonyms | DNA-binding protein Ikaros, Ikaros family zinc finger protein 1, Lymphoid transcription factor LyF-1, IKZF1, IK1, LYF1, ZNFN1A1 |
| Location | Nucleus |
| Accession | Q13422 |
| Clone Number | S-R264 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC | 1:500 | null |
| ICC | 1:500 | null |
| ICFCM | 1:5000 | null |
Background
Ikaros is a transcription factor that is encoded by the IKZF genes of the Ikaros family zinc finger group. Zinc finger is a small structural motif of protein that allows protein binding to DNA or RNA molecule that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold. Ikaros displays crucial functions in the hematopoietic system and is a known regulator of immune cells development, mainly in early B cells, CD4+ T cells. Its dysfunction has been linked to the development of chronic lymphocytic leukemia. In particular, Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia and that it also has a part in the differentiation and function of individual T helper cells.
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